His mother's death when he was aged six had a very profound effect on him.他6岁时母亲的过世对他的影响很大。
The invention of the contraceptive pill brought about profound changes in the lives of women.避孕药的发明给妇女的生活带来了深刻的变化。
Those two lines of poetry express perfectly the profound sadness of loss.那两行诗很好地表达了失去亲人的深切悲痛。
My grandfather has a profound mistrust of anything new or foreign.我祖父对任何新生或外来事物有一种根深蒂固的不信任。
There was a note of profound irritation in his voice.他的语气中带有强烈的恼怒情绪。