B2 the feeling that there is no hope and that you can do nothing to improve a difficult or worrying situation绝望
to cause someone such difficulties that they do not know how to deal with you成为…的心病,使…头疼
More examples
A feeling of despair descended on us as we realized that we were completely lost.
He was plunged into despair when his wife left him.
In despair, the theatre director searched everywhere for a new lead actor.
Over a bottle of wine, we shared our despair over the state of our marriages.
He sank into deep despair when he lost his job.
to feel despair about something or someone绝望;失去希望
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