B1 without taking any notice of or being influenced by; not prevented by不管;尽管;无论
If you do something despite yourself, you do it although you do not want to or although you know you should not.不由自主地,忍不住地
More examples
Trains are still running, despite the snow.
The pop festival passed off peacefully, despite the fears of local residents.
The overall situation is good, despite a few minor problems.
He was able to lead a normal life, despite the illness.
She manages to stay cheerful despite everything.
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